Dendritic Cells are antigen presenting cells and have high level of major histocompatibility complex, costimulatory molecules and cell adhesion molecules which are essential for antigen presentation.
When DC in the body present MHC class I coupled antigens, T cells recognize and destroy the tumour cells. The MHC class II antigen complex on the APC cell surface is recognized by the T cell antigen receptor (TCR).
The binding of the two is very specific and called as immunological synapse. The costimulatory receptor CD 28, binds DC cell adhesion molecules. The formation of TCR-MHC antigen complex sets off a cascade of events within the T cell resulting in gene activation and the ultimate result is cell proliferation. Certain Chemokine are released as a result of activation that plays an important role in cell activation.
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