Treatment of Oral Cancer
Cancer by far continues to be the most dreaded disease globally. Cancer is a term that encompasses a complex group of more than 150-200 different types of cancerous diseases . One such group of cancer is oral cancer, which includes commonly the tongue, floor of the mouth lips or roof of the mouth. Oral Cancer shows highest prevalence in India when compared to other countries. Prognosis of patients with advance stage or recurrent disease is poor mainly palliative and the mortality rate is high. Treatment modalities include surgery, radiation and chemotherapy. Surgery is effective for patients when the diagnosis is done at an early stage. Surgery along with locoregionalradition and chemotherapy gives survival not more than 5 years.
Because of its heterogeneity in terms of presentation, histology and tumour biology unique therapeutic interventions are needed. Recent studies have reported novel biological therapeutics importantly cell based immunotherapy with dendritic cells (DC) to treat cancer. It has been a promising approach for patients suffering with oral cancer.
Dendritic Cells are the professional antigen-presenting cells that form an integral part of innate and adaptive immunity. DCs can induce both the generation and proliferation of tumour specific T cells. Dendritic cell based therapy is a highly personalized option which may boost the body's immune response against the invading tumour. For therapy, monocytes are isolated from peripheral blood mononuclear cells by a procedure called leukapheresis. Monocytes are cultured in cocktails of cytokines which drives them to Dendritic Cell lineage which are then educated with tumour lysate. Mature tumour specific DCs are then administered back into patients. It can also be given as adjuvant with chemotherapy.