Initial recruitment of DC from the blood to peripheral sites occurs continuously in the steady state and is governed by chemokines, complement, cleavage products, defensins, and bacterial peptides (McWilliam et al. 1996; Sabatte et al. 2007; Sozzani 2005). Before activation, DC are considered immature with high endocytic capabilities and low expression of MHC and costimulatory molecules.. Read More

Simultaneously with antigen capture, processing, and presentation, DC also undergo an activation and maturation process that will ultimately enable them to migrate to lymphoid organs for the priming and activation of antigenspecific T cells. At the sites of local infection, DC encounter specific molecules that initiate their maturation. Read More

DC-directed Treatment of Bladder Cancer T-cell fate can be influenced by many factors including the nature of signal 3, pathogen type, route of pathogen delivery, tissue-derived environmental factors, other innate immune cells, and feedback signals from activated T cells (Diebold 2008). Read More

It is evident that fully mature DC, requiring the presence of all three T-cell stimulation signals, prime nai(ve Treatment of Liver Cancer T cells to elicit strong immune responses against invading pathogens. However, in the absence of the third signal, namely cytokines and other factors.. Read More